Razavi International Journal of Medicine

Published by: Kowsar

Effect of Amphotericin B on Treatment of Chronic Rhinosinusitis: A Double-blind Randomized Clinical Trial

Jaleh Yousefi 1 , Asghar Akhavan 1 , Reza Hoseini-Motlagh 2 , Shahin Banaei-Boroujeni 3 , Yunes Panahi 4 and Mohammad Hossein Khosravi 2 , 5 , *
Authors Information
1 Department of Otolaryngology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
2 Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
3 Department of Otolaryngology, Resident of Otolaryngology, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
4 Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
5 International Otorhinolaryngology Research Association (IORA), Universal Scientific Education and Research Network (USERN), Tehran, IR Iran
Article information
  • Razavi International Journal of Medicine: December 2017, 5 (4); e64550
  • Published Online: December 8, 2017
  • Article Type: Research Article
  • Received: January 28, 2017
  • Revised: February 22, 2017
  • Accepted: April 12, 2017
  • DOI: 10.5812/rijm.64550

To Cite: Yousefi J, Akhavan A, Hoseini-Motlagh R, Banaei-Boroujeni S, Panahi Y, et al. Effect of Amphotericin B on Treatment of Chronic Rhinosinusitis: A Double-blind Randomized Clinical Trial, Razavi Int J Med. 2017 ; 5(4):e64550. doi: 10.5812/rijm.64550.

Copyright © 2017, Razavi International Journal of Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Krous JHCS, Gordon BR, Derebery MJ. Allergy and immunology. 17 ed. Philadelphia: Lippincott Williams and Wilkings; 2002. p. 221-3.
  • 2. Hsu J, Peters AT. Pathophysiology of chronic rhinosinusitis with nasal polyp. Am J Rhinol Allergy. 2011;25(5):285-90. doi: 10.2500/ajra.2011.25.3680. [PubMed: 22186239].
  • 3. Choi SSGK, Kennedy DW, Bolger WE, Zinreich SJ. Complications in sinus disease. 14 ed. London: B. C. Decker Inc; 2001.
  • 4. Kern RC, Conley DB, Walsh W, Chandra R, Kato A, Tripathi-Peters A, et al. Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis. Am J Rhinol. 2008;22(6):549-59. doi: 10.2500/ajr.2008.22.3228. [PubMed: 18786300].
  • 5. National Center for Health Statistics . Summary health statistics for us adults, 1997, Data form the national health interview survey. Atlanta, USA; 2002.
  • 6. Kohatsu W. Complementary and alternative medicine secrets. Philadelphia: Hanley and Belfus; 2002.
  • 7. Kennedy DW, Bolger WE, Zinreich SJ. Diseases of the sinuses, diagnosis and management. Canada: PMPH, USA; 2001.
  • 8. Nuutinen J, Holopainen E, Haahtela T, Ruoppi P, Silvasti M. Balanced physiological saline in the treatment of chronic rhinitis. Rhinology. 1986;24(4):265-9. [PubMed: 3823748].
  • 9. Rudert H, Maune S, Mahnke CG. [Complications of endonasal surgery of the paranasal sinuses. Incidence and strategies for prevention]. Laryngorhinootologie. 1997;76(4):200-15. doi: 10.1055/s-2007-997414. [PubMed: 9264594].
  • 10. May M, Levine HL, Mester SJ, Schaitkin B. Complications of endoscopic sinus surgery: analysis of 2108 patients--incidence and prevention. Laryngoscope. 1994;104(9):1080-3. doi: 10.1288/00005537-199409000-00006. [PubMed: 8072353].
  • 11. Levine HL. Functional endoscopic sinus surgery: evaluation, surgery, and follow-up of 250 patients. Laryngoscope. 1990;100(1):79-84. doi: 10.1288/00005537-199001000-00016. [PubMed: 2293704].
  • 12. Wackym PA, Rice DH, Schaefer SD. Minimally invasive surgery of the head, neck, and cranial base. Philadelphia: Lippincott Williams and Wilkins; 2002.
  • 13. Rice DH, Schaefer SD, Calver LE. Endoscopic paranasal sinus surgery. Philadelphia: Lippincott Williams and Wilkins; 2004.
  • 14. Hosemann W. Minimally invasive endonasal sinus surgery thieme. 1 ed. New York: Stuttgart; 2000.
  • 15. Hamilos DL, Lund VJ. Etiology of chronic rhinosinusitis: the role of fungus. Ann Otol Rhinol Laryngol Suppl. 2004;193:27-31. [PubMed: 15174758].
  • 16. Ponikau JU, Sherris DA. The role of airborne mold in chronic rhinosinusitis. J Allergy Clin Immunol. 2006;118(3):762-3. doi: 10.1016/j.jaci.2006.06.035. [PubMed: 16950303].
  • 17. Shin SH, Ponikau JU, Sherris DA, Congdon D, Frigas E, Homburger HA, et al. Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol. 2004;114(6):1369-75. doi: 10.1016/j.jaci.2004.08.012. [PubMed: 15577837].
  • 18. Ponikau JU, Sherris DA, Kephart GM, Adolphson C, Kita H. The role of ubiquitous airborne fungi in chronic rhinosinusitis. Clin Rev Allergy Immunol. 2006;30(3):187-94. doi: 10.1385/criai:30:3:187.
  • 19. Wildfeuer A, Seidl HP, Paule I, Haberreiter A. In vitro evaluation of voriconazole against clinical isolates of yeasts, moulds and dermatophytes in comparison with itraconazole, ketoconazole, amphotericin B and griseofulvin. Mycoses. 1998;41(7-8):309-19. [PubMed: 9861837].
  • 20. Ponikau JU, Sherris DA, Weaver A, Kita H. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol. 2005;115(1):125-31. doi: 10.1016/j.jaci.2004.09.037. [PubMed: 15637558].
  • 21. Ebbens FA, Scadding GK, Badia L, Hellings PW, Jorissen M, Mullol J, et al. Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2006;118(5):1149-56. doi: 10.1016/j.jaci.2006.07.058. [PubMed: 17088142].
  • 22. Ricchetti A, Landis BN, Maffioli A, Giger R, Zeng C, Lacroix JS. Effect of anti fungal nasal lavage with amphotericin B on nasal polyposis. J Laryngol Otol. 2002;116(4):261-3. [PubMed: 11945184].
  • 23. Lund VJ, Mackay IS. Staging in rhinosinusitus. Rhinology. 1993;31(4):183-4. [PubMed: 8140385].
  • 24. Ponikau JU, Sherris DA, Kita H, Kern EB. Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2002;110(6):862-6. [PubMed: 12464951].
  • 25. Liang KL, Su MC, Shiao JY, Tseng HC, Hsin CH, Lin JF, et al. Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. Am J Rhinol. 2008;22(1):52-8. doi: 10.2500/ajr.2008.22.3115. [PubMed: 18284860].
  • 26. Shin SH, Ye MK. Effects of topical amphotericin B on expression of cytokines in nasal polyps. Acta Otolaryngol. 2004;124(10):1174-7. [PubMed: 15768813].
  • 27. Ebbens FA, Georgalas C, Luiten S, van Drunen CM, Badia L, Scadding GK, et al. The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study. Laryngoscope. 2009;119(2):401-8. doi: 10.1002/lary.20064. [PubMed: 19160404].
  • 28. Weschta M, Rimek D, Formanek M, Polzehl D, Podbielski A, Riechelmann H. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol. 2004;113(6):1122-8. doi: 10.1016/j.jaci.2004.03.038. [PubMed: 15208594].
  • 29. Helbling A, Baumann A, Hanni C, Caversaccio M. Amphotericin B nasal spray has no effect on nasal polyps. J Laryngol Otol. 2006;120(12):1023-5. doi: 10.1017/S0022215106002167. [PubMed: 16965642].
  • 30. Gerlinger I, Fittler A, Fonai F, Patzko A, Mayer A, Botz L. Postoperative application of amphotericin B nasal spray in chronic rhinosinusitis with nasal polyposis, with a review of the antifungal therapy. Eur Arch Otorhinolaryngol. 2009;266(6):847-55. doi: 10.1007/s00405-008-0836-0. [PubMed: 18953552].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments